| Pronunciation: DYE no PROS tone TOP ik al Brand: Cervidil, Prepidil, Prostin E2
| What is the most important information I should know about dinoprostone topical? |
 | • | You should not be treated with this medication if you are allergic to prostaglandins, or if you have active genital herpes with a vaginal lesion, placenta previa, or if your water has broken. |
| • | Be sure your doctor knows your entire pregnancy history, especially if you have ever had a C-section or major surgery on your uterus, if you have ever had a baby born in a breech position, or if you have ever had a difficult labor or delivery of a previous child. |
| • | Also tell your doctor if you have kidney or liver disease, glaucoma, or a history of asthma. |  | • | After you have received dinoprostone topical, tell your caregivers at once if your contractions slow down or become uneven, if you feel like you have a fever, or if you have any sudden vaginal bleeding. |
| What is dinoprostone topical? |
| • | Dinoprostone is a prostaglandin, a hormone-like substance that is naturally produced by tissues in the body. |
| • | Dinoprostone topical is used in a pregnant woman to relax the muscles of the cervix (opening of the uterus) in preparation for inducing labor at the end of a pregnancy. |
| • | Dinoprostone topical may be used for other purposes not listed in this medication guide. |
| What should I discuss with my health care provider before receiving dinoprostone topical? |
| • | You should not be treated with this medication if you are allergic to prostaglandins, or if you have certain conditions, such as: |
| · | active genital herpes with a vaginal lesion; |
| · | placenta previa (the placenta is below the fetus in your uterus); or |
| · | if your water has broken. |
| • | Be sure your doctor knows your entire pregnancy history, especially: |
| · | if you have ever had a C-section or major surgery on your uterus; |
| · | if you have ever had a baby born in a breech position (not head-first); or |
| · | if you have ever had a difficult labor or delivery of a previous child. |
| • | If you have any of these conditions, you may not be able to receive dinoprostone. |
| • | Before you receive dinoprostone, tell your doctor if you are allergic to any drugs, or if you have: |
| How is dinoprostone topical given? |
| • | Dinoprostone is a gel that is placed directly onto the cervix through the vagina using a special applicator. Your doctor, nurse, or other healthcare professional will give you this medication. |
| • | Dinoprostone is usually given while you are lying on your back. Your doctor may use a vaginal speculum to view your cervix. This will help your doctor determine how much of this medication to use. |
| • | After you are given this medication, you will need to remain lying down for at least 15 minutes unless your doctor tells you otherwise. | | • | If your uterus does not respond to dinoprostone within 6 hours, your doctor may apply a second dose. |
| • | If your uterus responds to the medication, you may begin having regular uterine contractions within a few hours. You may also be given other medications to help stimulate your uterine contractions and make them more regular. |
| What happens if I miss a dose? |
| • | Since dinoprostone is given as needed by a healthcare professional, it is not likely that you will miss a dose. |
| What happens if I overdose? |
| • | Tell your caregivers right away if you think you have received too much of this medicine. |
| • | Overdose symptoms may include increased contractions or more intense labor pains. |
| What should I avoid after receiving dinoprostone topical? |
| • | Follow your doctor's instructions about any restrictions on food, beverages, or activity after you are treated with dinoprostone. |
| What are the possible side effects of dinoprostone topical? |
| • | Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. | | • | Tell your caregivers at once if your contractions slow down or become uneven, if you feel like you have a fever, or if you have any sudden vaginal bleeding. |
| • | Less serious side effects may include: |
| · | feeling of warmth in the vaginal area. |
| • | This is not a complete list of side effects and others may occur. Tell your caregivers about any unusual or bothersome side effect. |
| What other drugs will affect dinoprostone topical? |
| • | This list is not complete and there may be other drugs that can interact with dinoprostone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor. |
| Where can I get more information? |
| • | Your doctor or pharmacist can provide more information about dinoprostone topical | |
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